With her first productions (Lortzings Der Wildschütz 2002 and Rossinis Il barbiere di Siviglia 2003, both at Vanemuine Theatre in Tartu) she introduced the Regietheater in Estonian opera. With her first productions (Lortzings Der Wildschütz 2002 and Rossinis Il barbiere di Siviglia 2003, both at Vanemuine Theatre in Tartu) she introduced the Regietheater in Estonian opera.

Staying open also to the traditional repertoire (staging e.g. one of the few productions of Beethovens Fidelio in Estonia in her own text version), she focused more and more on contemporary music theatre in its multiple forms including several world premiers. Among them the most important were . The formula of love by Mari Vihmand after Esther Vilárs Die Mathematik von Nina Gluckstein (Estonian National Opera 2008) which was nominated to the State Culture Award as well as They Went and Planted the Seeds of Shadows Because the Light Started to Sprout by Ardo Ran Varres (Festival Estonian Music Days, Tallinn 2016) or Etching.Ashes by Tatjana Kozlova-Johannes (Festival Estonian Music Days, Tallinn 2022).

On those works she collaborated with the composer from the very early stage giving dramaturgical advice and developing her stage direction parallel to the creation of libretto and music.

Liis Kolle also teaches young singers. From 2007 she is working at the opera studio of the Estonian Academy for Music and Theatre where she also managed an EU-funded project for integrating the teaching of contemporary music theatre into the curriculum of the opera studio. In this setting she also mentored PhD composition students to create short operas specially for the current voice students.

Since then she regularly works on modern operas at the opera studio like. With her students she also staged full-scale productions of Ravels L’enfant et les sortilèges, Handels Rinaldo as well as Blachers Abstrakte Oper Nr.1 (all were Estonian premiers).

Liis Kolle is also experienced with gala events, musical, cabaret and improvisation theatre. She has translated opera libretti and plays from Italian and German, acted as recitator and moderator and organised numerous cultural events in Estonia and Germany. She has received scholarships from the Bayreuth Festival, the Akademie Musiktheater heute at the Deutsche Bank Cultural Foundation, the Estonian Cultural Foundation and the Foundation for Estonian National Culture.

She lives in Berlin.